Frontline Combo Spot-On L for Dogs 20-40 kg – 3 Pipettes x 2.68 ml

For dogs weighing 20–40 kg, Frontline Combo Spot-On L delivers a dual-action formula that breaks the flea life cycle at every stage while also targeting ticks and biting lice. Unlike single-ingredient spot-ons that only kill adult fleas, this solution combines fipronil with (S)-methoprene to prevent reinfestation for up to 8 weeks. Each pipette contains 268 mg fipronil and 241.2 mg (S)-methoprene, providing a complete parasite control in one monthly application.

Highlights

• Dual-action formula: kills adult fleas, ticks, and biting lice, and stops flea eggs, larvae, and pupae from developing.
• Long-lasting protection: up to 8 weeks against fleas and up to 4 weeks against ticks.
• Water-resistant after 48 hours, so your dog can swim or be bathed without losing efficacy.
• Easy topical application with three 2.68 ml pipettes per pack – a three-month supply for a large dog.
• Over-the-counter availability, no veterinary prescription required.

In daily use

Apply the entire contents of one pipette directly to the skin between the shoulder blades once a month. The solution spreads over the body within 24 hours, providing continuous protection. For optimal tick control, reapply every 4 weeks; for fleas, the 8-week residual effect helps prevent reinfestation even if a dose is delayed. Safe for use in breeding, pregnant, and lactating dogs when used as directed.

Full specifications

• Product type: Spot-on parasiticide
• Target animal: Dogs
• Dog weight range: 20–40 kg
• Pack size: 3 pipettes
• Volume per pipette: 2.68 ml
• Active ingredient 1: Fipronil – 268 mg per pipette
• Active ingredient 2: (S)-Methoprene – 241.2 mg per pipette
• Targets: Fleas (adults, eggs, larvae, pupae), ticks, biting lice
• Flea efficacy duration: Up to 8 weeks
• Tick efficacy duration: Up to 4 weeks
• Application method: Topical spot-on
• Application frequency: Monthly
• Water resistance: Yes, after 48 hours
• Manufacturer: Boehringer Ingelheim Animal Health
• Veterinary prescription required: No

Final note

Frontline Combo Spot-On L is trusted by veterinarians worldwide for its proven efficacy and safety. With a simple monthly routine, you can keep your large dog protected from the discomfort and health risks of fleas, ticks, and lice all year round.